Irregular Levels of Dopamine Linked to Schizophrenia

 
Study Summary

This study examined the brains of 443 individuals (245 neurotypical individuals, 154 individuals with schizophrenia, and 44 individuals with bipolar disorder), 210 from African and 233 from European ancestries. Researchers identified many genes associated with schizophrenia risk, including the dopamine D2 receptor short isoform. This provides insight into risks for developing schizophrenia and potential therapies.

 
Study Citation

Benjamin, K. J. M., Chen, Q., Jaffe, A. E., Stolz, J. M., Collado-Torres, L., Huuki-Myers, L. A., Burke, E. E., Arora, R., Feltrin, A. S., Barbosa, A. R., Radulescu, E., Pergola, G., Shin, J. H., Ulrich, W. S., Deep-Soboslay, A., Tao, R., The BrainSeq Consortium, Hyde, T. M., Kleinman, J. E., Erwin, J. A., Weinberger, D. R., & Paquola, A. C. M. (2022). Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes. Nature Neuroscience, 25, 1559-1568 DOI: 10.1038/s41593-022-01182-7