Certain Risk Factors May Increase Probability of Developing PTSD

 
Study Summary

This study used stem cells from 19 combat veterans with PTSD and 20 combat veterans without PTSD to compare neuron responses to hydrocortisone exposure (stress hormone). Neurons in PTSD veterans were more hypersensitive and responsive to the stress hormone. This may indicate that there are risk factors that could increase the probability of developing PTSD following trauma exposure.

 
Study Citation

Seah, C., Breen, M. S., Rusielewicz, T., Bader, H. N., Xu, C., Hunter, C. J., McCarthy, B., Deans, P. J. M., Chattopadhyay, M., Goldberg, J., Desarnaud, F., Makotkine, I., Flory, J. D., Bierer, L. M., Staniskyte, M., NYSCF Global Stem Cell Array® Team, Noggle, S. A., Huckins, L. M., Paull, D., Brennand, K. J., & Yehuda, R. (2022). Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression. Nature Neuroscience. https://doi.org/10.1038/s41593-022-01161-y