Fasting May Improve Cognitive Decline Including Alzheimer's Disease

 
Study Summary

This study investigated the effects of fasting on cognitive decline. Using mice and a diet that mimics intermittent fasting and caloric restrictions, respectively, improved "age-related behavioral deficits". The results indicated a delay in cognitive decline in Alzheimer disease models in part by reducing neuroinflammation and/or superoxide production in the brain.

 
Study Citation

Rangan, P., Lobo, F., Parrella, E., Rochette, N., Morselli, M., Stephen, T., Cremonini, A. L., Tagliafico, L., Persia, A., Caffa, I., Monacelli, F., Odetti, P., Bonfiglio, P., Nencioni, A., Pigliautile, M., Boccardi, V., Mecocci, P., Pike, C. J., Cohen, P., LaDu, M. J., Pellegrini, M., Xia, K., Tran, K., Ann, B., Chowdhury, D., Longo, V. D. (2022). Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer’s models. Cell Report, 40(13). DOI:https://doi.org/10.1016/j.celrep.2022.111417